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BKchem
Free, portable, and open-source structure drawing program. Written in Python.
Chemical Drawing Programs Review
Detailed comparison between ISIS/Draw, ChemDraw, ChemWindow, ChemSketch, Chemistry 4-D Draw, WinPLT, MarvinSketch, ChemPen, WinDrawChem, and JChemPaint.
ChemicPen
Windows shareware for structure drawing. Download and ordering information.
ChemInnovation Software
Chemistry 4-D Draw high-quality structures quickly by entering molecular names. It also assigns systematic names, drawing and text editing.
ChemPen
Structure drawing, 3D modeling and NMR prediction. Demos and online ordering available.
Chemtool
Free software for drawing organic molecules and storing them as an X-Bitmap, LaTeX and XFig file. For Linux/Unix, includes source code, screenshots, and downloads.
ChemWindow
Program for drawing 2-D chemical structures, laboratory apparatus, and chemical engineering flowcharts.
EasyChem
Free Linux structure drawing program, designed with emphasis on press quality, speed of, precision, and ability to add arbitrary ornaments such as orbitals.
Gifcreator
Create GIFs and PNGs of 2D plots of chemical structures.
JChemPaint
Free, open-source editor for 2D chemical structures. Written in Java.
JME
Java based Molecular Editor which can create SMILES code.
JMolDraw
Drawing applet written in Java for use in database applications in chemistry.
PLT
Free structure drawing program for Windows; capable of exporting structures as metafiles, bitmaps, and HTML pages.
WinDrawChem/XDrawChem
Free structure drawing software for Windows and Unix, with simple spectral predictions. Source code available.