Combinatorial chemistry and self-assembling systems.

Organometallic chemistry.

New synthetic methods for natural product synthesis. Radical reactions, Lewis acid catalyzed reactions.

Structure elucidation, total synthesis, and determination of the mode of action of marine natural products that display significant physiological activity.

Synthesis of stereochemically complex, biologically active natural products. Design and synthesis of inhibitors of cysteine proteases isolated from tropical parasites.

Natural product synthesis, Prins cyclization, reductive decyanation, chiral auxiliaries for oxocarbenium ion reactions and methods for predicting molar rotations of acetonides.