Synthesis of complex organic compounds having interesting biological properties. New synthetic methodology, ranging from transition metal-catalyzed processes to novel electrocyclic reactions.

Asymmetric catalysis. Selective C- C bond formation and cleavage. Enzymatic oxidations. Mimics of physiologically important enzymes. New approaches to catalyst design.

Discovery and application of new reactions for organic synthesis.

Catalytic antibodies, combinatorial chemistry, enzyme inhibition and immunophamacotherapy.

Organic photochemistry, reactive intermediates, and sulfur chemistry.

New catalytic organic and organometallic transformations, their mechanism studies and their ultimate application to the total synthesis of architecturally challenging and biologically important natural products.

Asymmetric synthesis, natural product total synthesis, organometallic and coordination chemistry, ligand design, polymerization, methodology development, catalysis, enantioselective synthesis, non-natural amino acid synthesis.