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Gene Expression and Regulation
GenomeScan, GenScan Server, Mascot, MiCoViTo, Microarray Database Gateway, Psort
Genome Databases
Ensembl Genome Server, GenomeSeek, Human Ageing Genomic Resources, Human Genome Sequencing Center, Maize Genome Assembly Project, Mouse Genome Informatics, Rat Genome Database
Homology Detection
BLAST, ESPript, GeneMatcher, GeneStream II, GWBLAST, HMM library for all proteins of known structure, Interactive Blast Query, Meta-MEME v2.0.1, Sequence Alignment and Modeling System, The ISREC Group Servers
Molecular Biology Tools
NEBcutter, REBASE, WatCut, Webcutter 2.0
Phylogenetic Analysis
ClustalW, GRIMM/MGR, MultAlign, Phylogeny at Pasteur, SplitsTree 2, TreeGen, TreeTop, Vista tools
Protein Analysis
3D-JIGSAW, 3D-PSSM Fold Recognition, Betapred, Combinatorial Extension of Polypeptides, EMBL Bioinformatic Harvester, Entelechon Backtranslation tool, InterPro - The Integrated Resource of Protein Doma, JAligner, Jpred, Molecular Biology Tools Online
BIOBASE
The focus of the GBF project "Molecular Bioinformatics of Gene Regulation" are regulatory genomic signals and regions that govern transcriptional control based on TRANSFAC - The Transcription Factor Database. It compiles data about gene regulatory DNA sequences and protein factors binding to and acting through them.
BioGIS: Israel Biodiversity Information System
Israel Biodiversity Information System (BioGIS) is a Geographical Information System established to create a national database of the flora and fauna of Israel. The system is open to the public and provides advanced tools for querying, analyzing, modeling, and visualizing patterns of species distribution.
BioMolecular Engineering Research Center
Tools and methods for computational biology. Working on secondary protein structure prediction, providing reliable profiles, and developing new ways to study molecular biology through bioinformatics.
Biomolecular Interaction Network Database (BIND)
BIND is a database designed to store full descriptions of interactions, molecular complexes and pathways.
CAP Sequence Assembler
DNA sequence assembly and contig formation.
Carbohydrate-Active Enzymes (CAZy) database
Describes the families of structurally-related catalytic and carbohydrate-binding functional domains of enzymes that degrade, modify, or create glycosidic bonds.
Center Structural Biology: Programs and Tools
User guides and worked examples for software applications in structural and molecular biology - from Yale Univ.
CUBIC: Columbia University Bioinformatics Center
Features PredictProtein service for sequence analysis and protein structure prediction, META for single-page interface to validated sequence analysis, PredictNLS for prediction and analysis of nuclear localization signals, EVA for evaluation of automatic protein structure prediction servers, and DSSPcont for continuous assignment of protein secondary structure.
Database of Interacting Proteins (DIP)
The DIP catalogs experimentally determined interactions between proteins while combining information from a variety of sources to create a single, consistent set of protein-protein interactions.
Entrez Browser
Retrieves molecular biology data and bibliographic citations from the NCBI's integrated databases.
FIE (5' end Information Extraction)
Gene sequence extraction of regions around the 5'-end (promoter) and/or the translation initiation site (TIS) of a gene.
GeneCards: Human Genes, Proteins, and Diseases
Database of concise information about human genes (and their mouse homologs), focusing on their cellular functions and medical aspects - from the Weizmann Inst. of Science.
Genepop on the Web
Online version of the program for populational genetics.
General Repository for Interaction Datasets (GRID)
The GRID is a database of genetic and physical interactions. It contains interaction data from many sources, including several genome/proteome-wide studies, the MIPS database, and BIND
Geneva Bioinformatics (GeneBio) S.A.
GeneBio provides proteomics software tools and databases including SWISS-PROT, PROSITE, SWISS-2DPAGE and Melanie. We also offer a secure version of ExPASy molecular biology web server.
GenomeSURF
Colorful visualization of Sequence Frequency. Includes Human and Mouse Genomic Sequences. Evaluate uniqueness of graphically.
IBM Bioinformatics Group - Tools & Content
Several genomics and proteomics tools, including multiple alignments, gene expression analysis, tandem repeat and motif discovery.
INCBI Irish National Centre for BioInformatics
Hosts Irish embnet node, Gives links to Database browsing and interrogation at SRS, European (EBI) servers, Blast server for parasite genomes (EBI), US (NCBI) servers, Protein structure prediction, PredictProtein Server in Heidelberg, Gene identification, splice sites, exons, introns and a list of gene structure prediction programs
JustBio: Online Tool Set
A Suite of Online tools for analysis of DNA/RNA, Proteins, and Arrays.
Kangaroo
Search for motifs and paterns within amino acid and nucleotide databases
MedMiner
An Internet biomedical data-mining tool for organizing search information gathered from textual or genetic databases - from the NIH National Cancer Inst.
Melanie II 2-D Analysis Software
Powerful, state-of-the-art, 2-D analysis software package with user-friendly interface from the Swiss Institute of Bioinformatics (SIB).
Molecular Informatics Resource for the Analysis of
Information methodologies, tools, and technologies relating to the study of gene expression and signal transduction from the Institute for Transcriptional Informatics.
Molecular Interactions Database (MINT)
MINT is a database designed to store functional interactions between biological molecules (proteins, RNA, DNA).
NIH BioInformatics and Molecular Analysis Section
Numerous computational tools and resources to unite advances in biology with those in computers, informatics, and networking for the genomic and genetic analysis fields of BioInformatics; division of the Computational Bioscience and Engineering Lab at the Center for Information Technology.
Online Lab Reporting
A service that allows clinical laboratories to send test results to referring physicians over the internet. A help forum and FAQ pages are included.
PEDANT
Completely automatic and exhaustive analysis of protein sequence sets - from individual sequences to complete genomes
PIR-International Protein Sequence Database
produces a comprehensive, non-redundant, and expertly annotated protein sequence database. PIR features integrated annotation search to support functional/structural genomics and proteomic research.
PPO4 A phosphoproteomic Resource
A protein phosphorylation database and phosphoproteomic dataset repository
Protein Structure Prediction Using Web Resources
SPORes is a website for protein structure prediction using the web browser as an interface to software that runs of web servers or other resources available over the world wide web.
ProteinLounge
Bioinformatics portal which integrates protein information and many databases and research tools useful for researchers and students. Subscription based service.
ReadSeq
Convert various aminoacid and nucleotide sequence data formats including FASTA, GenBank, Phylip and others.
SA National Bioinformatics Institute
SANBI aims to bring genome information, computational biology, and analytical tools to the South African research community. Hosts SA National EMBNet Node, provides links to Sequence Retrieval System (SRS), GeneKraal, and TB Genomes Analysis Server. Research in Sequence Tag Alignment and Consensus Knowledgebase (STACK). Databases include BLAST search in Mycobacterium genome.
Scansite
Scansite searches for motifs within proteins that are likely to be phosphorylated by specific protein kinases or bind to domains such as SH2 domains, 14-3-3 domains or PDZ domains.
Searching GenBank
Text and similarity searching, provided by the National Center for Biotechnology Information (NCBI).
Sequence Analysis (Bielefeld University Bioinforma
Collection of sequence analysis tools.
The XEMBL Project
XEMBL provides access to the EMBL/GenBank/DDBJ Nucleotide Sequence Database, providing output in various XML standards.
Transcription Element Search Software (TESS)
Very helpful software for locating and displaying transcription factor binding sites within DNA sequences - from the Univ. of Penn.
TRANSFAC-The Transcription Factor Database
Very thorough compilation of transcriptional regulatory protein factors & their cognate gene promoter elements along with DNA sequence search & analysis programs - from GBF, Braunschweig, Germany.
Transterm - a database of mRNA regions and motifs
Transterm - an interactive database of mRNA regions and motifs from all species and genomes. Users can browse the pre-computed data tables, search the sequence databases or search their own sequences.
Verbumculus Genetic Sequence Analyzer
An interesting tool to discover and visualize over- or under-represented words in genetic sequences. Requires Java support in browser. Also available as a downloadable program.
Virtual Genome Center
Online computational resources for PCR primer selection, similarity searching- from the Univ. of Minnesota.
Web Services at Institute of Microbial Technology,
Protein structure prediction (Protein Structural Classes, Secondary Structure Prediction), immunological methods (ProPred), genomics & proteomics (Genome Wise Sequence Similarity Search, Spectral Repeat Finder, 2D Gel Comparison, protein coding gene by Fast Fourier Transform), and biological databases.
YMF - DNA Motif Finding Program
Finds novel transcription factor binding sites by searching for over-represented (most significant motifs) motifs in DNA sequences.