Primary mission is stewardship and maintenance of the U.S. nuclear weapons stockpile.

Responsibilities include FermiLab, Argonne National Laboratory, and Brookhaven National Laboratory

Conducts long-term environmental surveillance and maintenance of uranium mill tailings disposal sites and other waste sites and contaminated properties.

Manages major national programs in energy research, national defense, reindustrialization, and environmental cleanup. Based in Oak Ridge, Tennessee, with programs and facilities in five states.

Manages the following major research and development facilities report to OAK; Lawrence Livermore National Laboratory (LLNL), Lawrence Berkeley National Laboratory (LBNL), and Stanford Linear Accelerator Center (SLAC). The first two facilities are operated by the University of California (UC), while Stanford University operates SLAC.

Exists to clean up five former nuclear weapons production sites throughout Ohio and western New York state.

DOE Nevada Operations Office (Las Vegas) is responsible for the Nevada Test Site and other programs

A former uranium processing facility located in southwest Ohio undergoing environmental remediation.

On the Columbia River in southeastern Washington state, managed by the DOE Richland Operations Office. Served as a plutonium production complex for national defense for more than 50 years beginning with the Manhattan Project. Now the world's largest environmental cleanup project.

Oversees the operations of the Idaho National Engineering and Environmental Laboratory (INEEL).

Manages the cleanup activities at the Mound facility in Miamisburg, Ohio.

Maintains the capability at the Nevada Test Site and other facilities and sites to implement DOE initiatives in stockpile stewardship, crisis management, waste management, environmental management, nondefense research and development, and work for others

Where many underground and atmospheric tests of nuclear weapons were conducted

Responsible for the DOE Rocky Flats Site (formerly used for plutonium processing) in Colorado.

DOE facility located near Aiken, South Carolina. Also the home of the Savannah River Technology Center, an applied research and development (R&D) laboratory.

The Carlsbad Area Office leads the U.S. transuranic radioactive waste disposal efforts.