[8.1/10] Review by Carlos McElfish. "While the game is not terribly long it will provide around 15 full hours of entertainment before the end credits start to roll. If you're a fan of Duke Nukem, or just side-scrolling games in general I wholly recommend that you make haste to your local game-shop and pick this game up immediately."

[7.9/10] Review by Ron Dulin. "If you liked classic action games like Blackthorne or Flashback, or even the original Duke Nukem games, then you're sure to enjoy this attempt to make a modern update. Manhattan Project is occasionally frustrating, but when it's good, it's very, very good."

[7.8/10] Review by Sean "Agent 1337" M-J. "It's nice to see a new Duke Nukem on the market. If you've been a long-time fan of the series, go out and buy Duke Nukem: MP today. If you haven't been a huge fan in the past or are new to the name all together, you may want test it out before you buy. If you are looking for a new action, side-scrolling title, look no further than Duke Nukem, you will not be disappointed."

[83/100] Review by Bernard Dy. "It's great that Duke's character comes through so well, even with a development team different from the one that made Duke 3D. After a few levels I didn't even think about it being a side-scroller. I kept playing because I wanted to continue on with my adventures in the Manhattan Project."

[4/5] Review by David Laprad. "Yet none of these losses even begin to diminish what is (by all standards) a great game with cool visuals and sound, terrifically fun action and classic Duke Nukem attitude blazing from the gun barrels. Hail to the king, baby."